Murine Model of Sinusitis Infection for Screening Antimicrobial and Immunomodulatory Therapies
Alford MA, KYG Choi, MJ Trimble, H Masoudi, P Kalsi, D Pletzer, REW Hancock, (2021) Front Cell Infect Microbiol. 11:621081

Human organoid biofilm model for assessing antibiofilm activity of novel agents
Wu BC, EF Haney, N Akhoundsadegh, D Pletzer, MJ Trimble, AE Adriaans, PH Nibbering, REW Hancock, (2021) NPJ Biofilms Microbiomes 7(1):8

Recovery of Oral In Vitro Biofilms after Exposure to Peptides and Chlorhexidine
Zhang T, L Xia, Z Wang, REW Hancock, M Haapasalo, (2021) Journal of Endodontics 47(3):466-471

The value of antimicrobial peptides in the age of resistance.
Magana M, M Pushpanathan, AL Santos, L Leanse, M Fernandez, A Ioannidis, MA Giulianotti, Y Apidianakis, S Bradfute, AL Ferguson, A Cherkasov, MN Seleem, C Pinilla, C Fuente-Nunez, T Lazaridis, T Dai, RA Houghten, REW Hancock, GP Tegos (2020) Lancet Infect Dis. 20(9):e216-e230

Reassessing the Host Defense Peptide Landscape.
Haney EF, SK Straus, REW Hancock (2019) Front Chem. 7:43

Hyaluronic acid-based nanogels improve in vivo compatibility of the anti-biofilm peptide DJK-5.
Kłodzińska SN, D Pletzer, N Rahanjam, T Rades, REW Hancoc, HM Nielsen (2019) Nanomedicine 20:102022

A lipidic delivery system of a triple vaccine adjuvant enhances mucosal immunity following nasal administration in mice.
Wasan EK, J Syeda, S Strom, J Cawthray, REW Hancock, KM Wasan, V Gerdts (2019) Vaccine 37(11):1503-1515

Antimicrobial Effect of Peptide DJK-5 Used Alone or Mixed with EDTA on Mono- and Multispecies Biofilms in Dentin Canals.
Wang D, Y Shen, REW Hancock, J Ma, M Haapasalo (2018) Journal of Endodontics 44(11):1709-1713

Synergy between conventional antibiotics and anti-biofilm peptides in a murine, sub-cutaneous abscess model caused by recalcitrant ESKAPE pathogens
Pletzer D, SC Mansour, REW Hancock (2018) PLoS Pathog 14(6):e1007084

Computer-aided Discovery of Peptides that Specifically Attack Bacterial Biofilms
Haney EF, Y Brito-Sanchez, MJ Trimble, SC Mansour, A Cherkasov, REW Hancock (2018) Sci Rep. 8(1):1871

Treatment of Oral Biofilms by a D-Enantiomeric Peptide.
Zhang T, Z Wang, REW Hancock, C Fuente-Nunez, M Haapasalo (2016) PLoS One 11(11):e0166997

Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically.
Mansour SC, D Pletzer, C Fuente-Nunez, P Kim, GYC Cheung, HS Joo, M Otto, REW Hancock (2016) EBioMedicine 12:219-226

Treatment of Oral Multispecies Biofilms by an Anti-Biofilm Peptide.
Wang Z, C Fuente-Nunez, Y Shen, M Haapasalo, REW Hancock (2015) PLoS One 10(7):e0132512

D-enantiomeric peptides that eradicate wild-type and multidrug-resistant biofilms and protect against lethal Pseudomonas aeruginosa infections.
Fuente-Nunez C, F Reffuveille, SC Mansour, SL Reckseidler-Zenteno, D Hernandez, G Brackman, T Coenye, REW Hancock (2015) Chem Biol. 22(2):196-205

A broad-spectrum antibiofilm peptide enhances antibiotic action against bacterial biofilms.
Reffuveille F, C Fuente-Nunez, S Mansour, REW Hancock, (2014) Antimicrob Agents Chemother. 58(9):5363-71

Anti-Biofilm and Immunomodulatory Activities of Peptides That Inhibit Biofilms Formed by Pathogens Isolated from Cystic Fibrosis Patients.
Fuente-Nunez C, S Mansour, Z Wang, L Jiang, EBM Breidenstein, M Elliott, F Reffuveille, DP Speert, SL Reckseidler-Zenteno, Y Shen, M Haapasalo, REW Hancock, (2014) Antibiotics (Basel) 3(4):509-26

Novel vaccine formulations against pertussis offer earlier onset of immunity and provide protection in the presence of maternal antibodies.
Polewicz M, A Gracia, S Garlapati, J van Kessel, S Strom, SA Halperin, REW Hancock, AA Potter, LA Babiuk, V Gerdts (2013) Vaccine 31(31):3148-55

Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles.
Garlapati S, R Garg, R Brownlie, L Latimer, E Simko, REW Hancock, LA Babiuk, V Gerdts, A Potter, S van Drunen Littel-van den Hurk (2012) Vaccine 30(35):5206-14

Comparison of immune responses and protective efficacy of intranasal prime-boost immunization regimens using adenovirus-based and CpG/HH2 adjuvanted-subunit vaccines against genital Chlamydia muridarum infection.
Brown THT, J David, E Acosta-Ramirez, JM Moore, S Lee, G Zhong, REW Hancock, Z Xing, SA Halperin, J Wang (2012) Vaccine 30(2):350-60

Cathelicidin Host Defense Peptides and Inflammatory Signaling: Striking a Balance
Alford MA, B Baquir, FL Santana, EF Haney, REW Hancock (2020) Front Microbiol. 11:1902

Influence of Non-natural Cationic Amino Acids on the Biological Activity Profile of Innate Defense Regulator Peptides.
Haney EF, SC Barbosa, B Baquir, REW Hancock (2019) J Med Chem. 62(22):10294-10304

Identification of an IDR peptide formulation candidate that prevents peptide aggregation and retains immunomodulatory activity.
Haney EF, KC Wuerth, NRahanjam, NS Nikouei, A Ghassemi, MA Noghani, A Boey, REW Hancock (2018) Peptide Science 111:1.e24077

Characterization of Host Responses during Pseudomonas aeruginosa Acute Infection in the Lungs and Blood and after Treatment with the Synthetic Immunomodulatory Peptide IDR-1002.
Wuerth K, AHY Lee, R Falsafi, EE Gill, REW Hancock (2018) Infect Immun. 87(1):e00661-18

Induction by innate defence regulator peptide 1018 of pro-angiogenic molecules and endothelial cell migration in a high glucose environment.
Marin-Luevano P, V Trujillo, A Rodriguez-Carlos, I Gonzalez-Curiel, JA Enciso-Moreno, REW Hancock, B Rivas-Santiago (2018) Peptides 101:135-144

Synthetic host defense peptide IDR-1002 reduces inflammation in Pseudomonas aeruginosa lung infection.
Wuerth KC, R Falsafi, REW Hancock (2017) PLoS One 12(11):e0187565

Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model.
Wu CB, AHY Lee, REW Hancock, (2017) J Immunol. 199(10):3592-3603

Aggregation and Its Influence on the Immunomodulatory Activity of Synthetic Innate Defense Regulator Peptides.
Haney EF, CB Wu, K Lee, AL Hilchie, REW Hancock (2017) Cell Chem Biol. 24(8):969-980.e4

An Immunomodulatory Peptide Confers Protection in an Experimental Candidemia Murine Model.
Freitas CG, SMF Lima, MS Freire, APC Cantuária, NGO Júnior, TS Santos, JS Folha, SM Ribeiro, SC Dias, TMB Rezende, P Albuquerque, AM Nicola, C de la Fuente-Núñez, REW Hancock, OL Franco, MSS Felipe. (2017) Antimicrob Agents Chemother. 61(8):e02518-16.

The immunology of host defence peptides: beyond antimicrobial activity.
Hancock REW, EF Haney, EE Gill (2016) Nat Rev Immunol 16(5):321-34

Peptide IDR-1002 Inhibits NF-κB Nuclear Translocation by Inhibition of IκBα Degradation and Activates p38/ERK1/2-MSK1-Dependent CREB Phosphorylation in Macrophages Stimulated with Lipopolysaccharide.
Huante-Mendoza A, O Silva-García, J Oviedo-Boyso, REW Hancock, VM Baizabal-Aguirre, (2016) Front Immunol. 7:533

Anti-infective peptide IDR-1002 augments monocyte chemotaxis towards CCR5 chemokines.
Madera L, REW Hancock (2015) Biochem Biophys Res Commun 464(3):800-6

The innate defense regulator peptides IDR-HH2, IDR-1002, and IDR-1018 modulate human neutrophil functions.
Niyonsaba F, LMadera, NAfacan, K Okumura, HOgawa, REW Hancock (2013) J Leukoc Biol. 94(1):159-70

Immune modulation by multifaceted cationic host defense (antimicrobial) peptides.
Hilchie AL, K Weurth, REW Hancock (2013) Nat Chem Biol. 9(12):761-8

Ability of innate defence regulator peptides IDR-1002, IDR-HH2 and IDR-1018 to protect against Mycobacterium tuberculosis infections in animal models.
Rivas-Santiago B, JE Castañeda-Delgado, CE Rivas Santiago, M Waldbrook, I González-Curiel, JC León-Contreras, JA Enciso-Moreno, Vdel Villar, J Mendez-Ramos, REW Hancock, R Hernandez-Pando (2013) PLoS One 8(3):e59119

Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.
Pena OM, N Afacan, J Pistolic, C Chen, L Madera, R Falsafi, CD Fjell, REW Hancock (2013) PLoS One 8(1):e52449

Innate defense regulator peptide 1018 in wound healing and wound infection.
Steinstraesser L, T Hirsch, M Schulte, M Kueckelhaus, F Jacobsen, EA Mersch, I Stricker, N Afacan, H Jenssen, REW Hancock, J Kindrachuk (2012) PLoS One 7(8):e39373

Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts.
Turner-Brannen E, KY Choi, DND Lippert, JP Cortens, REW Hancock, H El-Gabalawy, N Mookherjee, (2011) Arthritis Res Ther. 13(4):R129